A2504
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A2504
Sigma
6-Aminocaproic acid
≥99% (titration), powder
| Synonym: | ε-Aminocaproic acid, 6-Aminohexanoic acid, EACA |
| CAS Number: | 60-32-2 |
| Linear Formula: | H2N(CH2)5CO2H |
| Molecular Weight: | 131.17 |
| Beilstein Registry Number: | 906872 |
| EC Number: | 200-469-3 |
| MDL number: | MFCD00008238 |
| PubChem Substance ID: | 24890662 |
Description
| Application | EACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl2, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature. |
| Biochem/physiol Actions | EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carboxypeptidase, plasmin, and plasminogen activator. |
| Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis.1,2 Reported to inhibit plasminogen binding to activated platelets.3 An early report indicated that it inhibits the activation of the first component of the complement system.4 Binds and inactivates Carboxypeptidase B.5 |
Properties
| assay | ≥99% (titration) |
| form | powder |
| color | white |
| mp | 207-209 °C (dec.)(lit.) |
| solubility | H2O: 50 mg/mL |
| Gene Information | human ... PLG(5340) |
| rat ... Ppm1a(24666) |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 2 |
| RTECS | MO6300000 |
References
| Cited Reference | 1. Humphries, J.E., et al., Fibrinogenolytic and fibrinolytic activity of cell-associated plasmin,. Arterioscler. Thromb. 13, 48-55, (1993) |
| 2. Krishnamurti, C., et al., Inhibitory effects of lysine analogues on t-PA induced whole blood clot lysis. Thromb. Res. 73, 419-430, (1994) | |
| 3. Adelman, B., et al., Plasminogen interactions with platelets in plasma. Blood 72, 1530-1535, (1988) | |
| 4. Soter, N.A., et al., Inhibition by ε-aminocaproic acid of the activation of the first component of the complement system,. J. Immunol. 114, 928, (1975) | |
| 5. Dessaint, J.P., et al., Catheptic carboxypeptidase B as a major component in "T-cell activating factor" of macrophages. J. Immunopharmacol. 1, 399-414, (1979) | |
| Merck | Merck 13,431 |
| Beilstein | Beil. 4,IV,2695 |
| reference | Aldrich MSDS 1, 67:B / Corp MSDS 1 (1), 149:B / FT-IR 2 (1), 919:B / FT-IR 1 (1), 578:D / IR-Spectra (3), 345:F / IR-Spectra (2), 308:A / NMR-Reference 2 (1), 490:C / RegBook 1 (1), 659:G / Sax 6, 205 / Sigma FT-IR 1 (1), 33:B / Structure Index 1, 97:B:8 |
